A detailed explanation of the PGTseq-M method and its requirements is given in the Juno Genetics User Manual. In brief, Juno can begin work on a new PGTseq-M test once it has received the following: 1) a genetic report describing the mutation(s) responsible for the disorder for which PGTseq-M is being requested; 2) blood samples from the couple requesting PGTseq-M (both the man and the woman, even if only one of them carries a mutation); 3) where possible a sample from a child or other close relative who has been tested for the mutation (blood, DNA or saliva); 4) a completed Requisition Form, confirming the request for PGTseq-M and providing relevant information concerning the patients. In rare cases, PGTseq-M is not technically possible. Additionally, PGTseq-M often requires several weeks in order to develop and validate a new test. For these reasons, patients should not begin a cycle until Juno has confirmed that a PGTseq-M test has been successfully developed.
